Kubva pakuona kwenhoroondo yebudiriro yeindasitiri yezvemishonga yeChina, mushure memakore anoda kusvika makumi matatu ebudiriro, vepakati vemishonga vakagadzira kubva kubazi diki reindasitiri yemakemikari kuita indasitiri iri kusimukira ine kukosha kwemabhiriyoni emayuan, uye makwikwi ayo emusika kuwedzera kutyisa.

Zvinonzwisiswa kuti mukutanga danho rekuvandudzwa kweindasitiri yemishonga yepakati, nekuda kwekudyara kudiki uye chiyero chekudzoka chakakwira, mabhizinesi epakati pemishonga akaita sehowa, kunyanya muZhejiang, Taizhou, Nanjing nedzimwe matunhu ane mamiriro akanaka ekusimudzira. pharmaceutical intermediates development inokurumidza zvikuru.

Parizvino, sekuchinja kwemaitiro emusika wekurapa, pamwe nekugadzirwa kwemishonga mitsva pamusika kushoma, kuomerwa kwemishonga inopindirana neindasitiri yekugadzirwa kwechigadzirwa kunowedzera kukura, chigadzirwa chechinyakare chiri kuramba chichiwedzera kukwikwidza kunotyisa. , Pharmaceutical intermediates indasitiri purofiti yakadonha nekukurumidza, uye vepakati vemishonga vanova vanofanirwa kufunga nezve dambudziko rekusimudzira kwebhizinesi.

Iyo indasitiri inotenda kuti zvinogoneka kuumba yayo yemakwikwi mukana kubva kuzvinhu zvetekinoroji, pesvedzero uye shanduko, kuitira kumira kunze mumusika.

Panyaya yetekinoroji, inonyanya kutaura nezvekuvandudza tekinoroji uye kuchengetedza mutengo.Inoshumwa kuti nzira yekugadzira mishonga yepakati yakareba, danho rekuita rakawanda, kushandiswa kwesolvent kwakakura, kugona kuvandudza kwehunyanzvi kwakakura.

Semuyenzaniso, zvinhu zvisinganyanyi kukosha zvinogona kushandiswa pachinzvimbo chezvakanyanya kukosha, senge bromide yemvura mukugadzirwa kweaminothioamidic acid uye ammonium thiocyanate mukugadzira pachinzvimbo che potassium thiocyanate (sodium).

Mukuwedzera, imwe solvent inogona kushandiswa kutsiva zvakasiyana-siyana zvinonyungudutsa mukuita maitiro, uye madoro anogadzirwa kubva kuhydrolysis yezvigadzirwa zve ester zvinogona kudzoserwa.

Panyaya yepesvedzero, inonyanya kuumba zvigadzirwa zvayo uye inovandudza simba rayo muindasitiri. zvimwe zvakanakira pamusika.

Panyaya yeshanduko, pari zvino, nekuomarara kwekuchengetedza kwezvakatipoteredza zvinodiwa muChina, zviwanikwa zvakarerekera kumaindasitiri akawedzera-kukosha, uye nekuwedzera kwemitengo yekuchengetedza kwezvakatipoteredza, shanduko yave dambudziko rinofanirwa kutariswa kuitira kusimudzira kwakasimba. zvemabhizimusi epakati pemishonga.

Zvinokurudzirwa kuti mabhizinesi epakati pemishonga anofanirwa kuwedzera cheni yeindasitiri kumusoro nekudzika, uye kutendeutsa iwo makuru zvigadzirwa zvavanoshandisa kuita kugadzirwa kwavo.Nenzira iyi, mutengo unogona kudzikiswazve, uye kune zvimwe zvakakosha zvigadzirwa, iyo monopoly yezvinhu zvakakosha mbishi inogona kudzivirirwa.

Indasitiri inotaura kuti kuderera, umo mishonga yepakati inogadzirwa zvakananga muapis, inogona kuwedzera kuwedzera kukosha kwezvigadzirwa pavanenge vachizvitengesa zvakananga kumakambani emishonga. Zvakakosha kuziva kuti kune mari yakawanda mukuwedzera kwepasi, zvakare. sechinodikanwa chepamusoro chekugadzira tekinoroji uye hukama hwakanaka nevashandisi veAPI.Muzhinji, mabhizinesi anotungamira achawana mamwe mabhenefiti emakwikwi.

Pamusoro pezvo, tsvakiridzo nebudiriro yakakosha zvikuru kuindasitiri yepakati.Parizvino, indasitiri yepakati yemishonga yekuChina kazhinji haitarisire kutsvagisa nekusimudzira. Naizvozvo, mumamiriro ekugara achivandudza zvinodiwa zvehunyanzvi, mabhizinesi eR&D ane simba rakasimba reR&D achauya pamberi, nepo mabhizinesi madiki nepakati asina r&d kugona anogona. kubviswa nemusika.Mune ramangwana, iyo indasitiri yekutarisa ichawedzera kuvandudzwa uye yepakati uye yakaderera-yekupedzisira nhanho yekusimudzira ichasimudzirwa kusvika padanho repamusoro.