MIT-Ivy Indasitiri ibhizimusi remishonga uye chemakemikari repakati rinobatanidza kugadzira, kutengesa uye kutsvagisa kwesainzi.Nezvigadzirwa zvemhando yepamusoro zvekugadzira uye tekinoroji yekugadzira, tinochengeta hukama hwakanaka hwekushandira pamwe nemasangano ekutsvagisa kwesainzi uye mayunivhesiti makuru uye epakati. Isu tinonyanya kuita basa rekugadzira nekutengesa kweakatevedzana emishonga yepakati, kunyanya mukurapa kweAids, moyo uye cerebrovascular zvinodhaka, uye kutsigira pakati pemishonga inorwisa-kuzvimba. Zvigadzirwa zve sodium azide, triphenyl chloromethane, L- valine methyl ester hydrochloride inotengeswa kumba uye kunze kwenyika.1. Nhanganyaya yemishonga yepakati Mishonga yepakati inoreva zvigadzirwa zvepakati senge mbichana, midziyo uye zvinhu zvinobatsira zvinoshandiswa mukugadzirwa kwemishonga yemishonga.Kutaura zvazviri, iwo mamwe makemikari anogadzirwa kana zvigadzirwa zvemakemikari mukugadzira zvinodhaka.Mufananidzo Vagadziri vemishonga inotengeswa. uye inoshanda zvinodhaka zvinhu zvinoda kugamuchira GMP certification. Pharmaceutical intermediates, kunyangwe ichishandiswa mukugadzira zvinodhaka, ingori kusanganisa uye kugadzirwa kwemakemikari zvigadzirwa. Ndiwo akanyanya kukosha uye epasi zvigadzirwa mumaketani ekugadzira zvinodhaka uye haakwanise kunzi mishonga, saka GMP certification haidiwe.Mishonga yepakati inogona kugadzirwa mune zvakajairika makemikari zvirimwa uye inogona kushandiswa mukugadzirwa kwemishonga kune mamwe mazinga. inoderedzawo chikumbaridzo chekupinda cheindasitiri yevagadziri vepakati.Mufananidzo2. Huyero hweindasitiri yemishonga yepakatiNekugadziridzwa kwechimiro cheindasitiri, kuendesa kugadzirwa kwepasi rose uye kumwe kunatsiridzwa kwechikamu chepasi rose chevashandi vemakambani makuru emishonga emarudzi mazhinji, China yave nzvimbo yakakosha yepakati yekugadzira muchikamu chepasi rose chevashandi veindasitiri yemishonga. Maererano neKutsvagisa Chirevo pamusoro peKuvandudza kweChina's Pharmaceutical Intermediates Industry (2016), kubva muna 2011 kusvika muna 2015, indasitiri yemishonga yeChina yemishonga uye kukosha kwayo kwese kwakawedzera gore negore, nehuwandu hwekukura kwegore hunosvika 13.5%. yemishonga intermediates muChina yakasvika 422.56 bhiriyoni yuan muna 2015, kuwedzera 9,88% gore negore. yuan na2020.Mufananidzo3. Indasitiri ine hunyanzvi hwepakati pemishongaIndasitiri iri kudiwa nekukurumidzira kugadzirisa uye kusimudzira: huwandu hwese hwehunyanzvi hweChina huchiri hushoma, uye kune mashoma emabhizinesi ari kugadzira huwandu hukuru hwepamberi hwemishonga yepakati uye inotsigira yepakati yemishonga mitsva ine patented, iri mukuvandudza. nhanho yekugadzirwa kwechigadzirwa optimization uye upgrading.Mamwe mabhizinesi chete ane tsvakiridzo yakasimba uye simba rekusimudzira, zvivakwa zvekugadzira zvepamberi uye ruzivo rwakakura rwekugadzira anogona kuwana purofiti yakakura mumakwikwi.Stable bhizinesi chiyero: Makuru-anogadzira vanotora yakagadziridzwa kugadzirwa seyavo huru. bhizinesi modhi. Pasi pemhando yekugadzira yakasarudzika, hukama hwekushandira pamwe pakati pevatengi vakuru nevatengesi hune kugadzikana, uye kuswedera pedyo kwekushandira pamwe, kunowedzera dhigirii rekuvimba, uye mapoka ekubatana anopihwa nevatengi vakuru achave. Zvinotora nguva yakareba kuchinja. suppliers. Naizvozvo, sebhizimusi rine kusimba kwakasimba, makambani emishonga epakati peindasitiri anonyanya kutarisisa makambani emishonga ekunze anonyanyozivikanwa panguva ino. nyika yakagadzikana.Kutengeswa kunze kwenyika zvakanyanya: nzvimbo huru dzekutengesa mishonga muChina iEU, North America, Middle East, Southeast Asia, etc.Kutengeswa kwenyika yedu kunonyanya kukoshesa vitamin C, penicillin, acetaminophen, citric acid. uye munyu wayo uye esters, senge zvigadzirwa, hunhu hwezvigadzirwa kugadzirwa kwezvigadzirwa, mabhizinesi ekugadzira, makwikwi emusika akanyanya, mutengo wechigadzirwa uye mutengo wakawedzerwa wakadzikira, kugadzirwa kwakawanda kwazvo kwakakonzera misika yepakati yemishonga yemusika. Zvigadzirwa zvemhando yepamusoro-soro zvichiri kunyanya kutengwa kunze kwenyika. Mabhizinesi madiki uye epakati nepakati: mabhizinesi ekugadzira anonyanya kuve ega ega, anochinjika kushanda, chiyero chekudyara hachisi chikuru, chiri pakati pemamiriyoni kusvika gumi kana makumi maviri emamiriyoni yuan. Regional concentration: kugoverwa kwedunhu mabhizinesi ekugadzira akatarisana, akatenderedza akati wandei mafekitori emishonga, anonyanya kugoverwa muTaizhou, Zhejiang neJintan, Jiangsu sepakati pedunhu. Zhejiang Huangyan, Taizhou, Nanjing Jintan, Shijiazhuang, Jinan (kusanganisira Zibo), kuchamhembe kwakadziva kumabvazuva (Siping, Fushun). ) uye dzimwe nzvimbo dzine mamiriro akanaka ekugadzirwa kwemishonga yepakati dzakakura zvakanyanya.Kukurumidza chigadzirwa chekuvandudza: chigadzirwa chinowanzo pamusika makore matatu kusvika mashanu gare gare, purofiti yayo inodonha zvakanyanya, izvo zvinomanikidza mabhizinesi kugara achigadzira zvigadzirwa zvitsva. kana kugara uchivandudza maitiro ekugadzira, kuitira kuchengetedza purofiti yakakura yekugadzira. Kukwikwidza kwakanyanya: nekuti purofiti yekugadzira yemishonga yepakati yakakwira kupfuura yezvigadzirwa zvemakemikari, uye maitiro ekugadzira maviri acho akafanana, akawedzera uye madiki. makambani emakemikari anobatana nekugadzirwa kwemishonga yepakati, zvichiita kuti pave nemakwikwi anotyisa asina kunaka muindastiri.4. Mhando dzemishonga yepakatiKune marudzi akawanda emishonga epakati, anosanganisira cephalosporin intermediates, amino acid protectant series, vitamin intermediates, quinolone intermediates, nemamwe marudzi epakati, akadai semishonga inouraya utachiona hwepakati, antiepileptic drug intermediates, fluoropyridine intermediate, pharmacetics, etc. .Maererano neminda yavo yekushandisa, vanogona kukamurwa kuita antibiotic drug intermediates, antipyretic uye analgesic drug intermediates, cardiovascular system drug intermediates, anti-cancer drug intermediates uye zvichingodaro.Parizvino, kune mazana emishonga yepakati pemishonga, uye nguva dzose. innovate, kuumba maindasitiri akawanda akanaka ma molecular industries mu pharmaceutical intermediates industry.Kune marudzi akawanda ezvakasiyana zvemishonga intermediates.Senge imidazole, furan, phenolic intermediates, aromatic intermediates, pyrrole, pyridine, biochemical reagents, sulfur, nitrogen, haterocyclic compounds, heterocyclic compounds, , microcrystalline cellulose, starch, mannitol, lactose, dextrin, ethylene glycol, shuga yehupfu, inorganic munyu, ethanol intermediates, stearic acid, amino acid uye ethanol amine munyu, sylvite, sodium munyu uye mamwe intermediates uye zvichingodaro.Mufananidzo5. Patent CliffKubvira 2000, musika wepasi rose wemagetsi wakaramba uchikura nekukurumidza kupfuura musika wese wemishonga, uchikura nekaviri nekukurumidza semishonga ine patent. musika wezvinodhaka kubva 2005 kusvika 2013 unotarisirwa kusvika 14.7%.Musika wepasi rose wegenerics unotarisirwa kukura ne10% kusvika 14% mumakore mashanu anotevera, nekukurumidza zvakanyanya kupfuura zvaitarisirwa kukura kwe4% kusvika 6% kweindasitiri yese yemishonga. Zvinogona kufungidzirwa kuti kusimukira kwemusika wemishonga yegeneric kuchasimudzira kuvandudzwa kweindasitiri yemishonga yepakati.Kubva 2010 kusvika 2020, musika wepasi rose wemishonga uchaunza mafungu ekupera kwePatent, pakati pawo, kubva 2013 kusvika 2020, iyo yepasi rose Patent kupera kwemhando yemhando inodarika mazana maviri pagore, iyo inozivikanwa se "Patent Cliff" munyika.Muna 2014, pachava nepamusoro-soro yekupera kwemishonga patent, umo kuchava nepamusoro mu2014, ne 326 mishonga yepatent inopera. 2010 na2017 ndiwo makore maviri epamusoro, aine mazana maviri neshanu uye 242 emishonga patent achipera zvichiteerana. Mishonga yakapera inonyanya anti-infective, endocrine, nervous system uye mishonga yemwoyo, ine misika yakakura yemusika.Kupera kukuru kwemishonga ine mvumo yekunze kune dzimwe nyika kunounza zvitsva zvinokonzera kumishonga yemishonga yepakati muChina.Nekuti mushure mekupera kwepatent. madhiragi, kugadzirwa kwemishonga inechekuita negeneric kuchaputika, izvo zvichafambisa kukurumidza kukura kwechido chepakati chemishonga chine hukama.Mufananidzo6. Environmental pressureChina yatova mutengesi mukuru we API intermediates, pamwe nekusvibisa kukuru.Pharmaceutical yepakati vanogadzira ndevefine chemical industry, pachava nekuenderana nekusvibiswa kwengozi.According to statistics from the Ministry of Environmental Protection, the total output value of the indasitiri yemishonga yemumba inodarika 3 muzana yeGDP yenyika, asi huwandu hwehuwandu hwekusvibiswa kwemhepo hunosvika 6 muzana. Pakati pemarudzi ese emishonga, API inonyanya kumiririrwa nemavhitamini uye penicillin ndeyeindasitiri yekusvibiswa kwepamusoro uye kushandiswa kwesimba kwakanyanya, Zvinoenderana nekutumirwa kwakabatana kweMinistry of Environmental Protection, musi waFebruary 15, 2017, boka rekuongorora rakakosha yehutano hwemhepo mukota yekutanga ye2017 yakazivisa kuti kushandiswa kwemhepo muShijiazhuang kwakanga kusiri. panzvimbo, uye hurumende yedunhu yakanga ichiri kunyanya kubva pavashandi veEnvironmental Protection Bureau mukushandiswa kwehurongwa hwekusvibiswa kwemamiriro ekunze hunorema, nepo mamwe madhipatimendi asina kubatanidzwa mune dhigirii repamusoro. kugadzira mishonga yepakati muShijiazhuang yakakomba.Mabhizimisi emishonga ane teknolojia yakadzokera shure achatakura mari yakawanda yekudzora kusvibiswa uye kudzvinyirira kwemitemo, uye mabhizimisi emishonga echinyakare anonyanya kubudisa kusvibiswa kwepamusoro, kushandiswa kwesimba guru uye zvigadzirwa zvakaderera (zvakadai sepenicillin, mavitamini, nezvimwewo. ) ichatarisana nekukurumidzira kubviswa. Kuomerera pakugadzira zvinhu zvitsva uye kugadzira tekinoroji yemishonga yegirinhi yave nzira yebudiriro yeramangwana yeindasitiri yemishonga yepakati. Mufananidzo
7. Vatungamiri vemaindasitiri
mit-ivy industry
Zhejiang NHU Company Ltd.Plo Co., Ltd
Lianhe Chemical Technology Co., Ltd.Anhui Bayi Chemical Co. Ltd.Zhejiang Huahai Pharmaceutical Co. Specialty Chemicals Co., Ltd.