MIT-Ivy Indasitiri ibhizimusi remishonga nemakemikari repakati rinobatanidza kugadzira, kutengesa uye kutsvagisa kwesainzi.Nezvigadzirwa zvemhando yepamusoro zvekugadzira uye tekinoroji yekugadzira, tinochengeta hukama hwakanaka hwekushandira pamwe nemasangano ekutsvagisa kwesainzi nemayunivhesiti makuru uye epakati.Isu tinonyanya kuita basa rekugadzira nekutengesa kweakatevedzana emishonga yepakati, kunyanya mukurapa kweAids, moyo uye cerebrovascular zvinodhaka, uye kutsigira pakati pemishonga inorwisa-kuzvimba. Zvigadzirwa zve sodium azide, triphenyl chloromethane, L- valine methyl ester hydrochloride inotengeswa kumba uye kunze kwenyika.1.Nhanganyaya yemishonga yepakati Mishonga yepakati inoreva zvigadzirwa zvepakati senge mbichana, midziyo uye zvinhu zvinobatsira zvinoshandiswa mukugadzirwa kwemishonga yemishonga.Kutaura zvazviri, iwo mamwe makemikari anogadzirwa kana zvigadzirwa zvemakemikari mukugadzira zvinodhaka.Mufananidzo Vagadziri vemishonga inotengeswa. uye inoshanda zvinodhaka zvinhu zvinoda kugamuchira GMP certification.Pharmaceutical intermediates, kunyangwe ichishandiswa mukugadzira zvinodhaka, ingori musanganiswa uye kugadzirwa kwekemikari mbishi zvinhu.Ndiwo akanyanya kukosha uye epasi zvigadzirwa mumaketani ekugadzira zvinodhaka uye haakwanise kunzi mishonga, saka GMP certification haidiwe.Mishonga yepakati inogona kugadzirwa mune zvakajairika makemikari zvirimwa uye inogona kushandiswa mukugadzirwa kwemishonga kune mamwe mazinga. inoderedzawo chikumbaridzo chekupinda cheindasitiri yevagadziri vepakati.Mufananidzo2.Huyero hweindasitiri yemishonga yepakatiNekugadziridzwa kwechimiro cheindasitiri, kuendesa kugadzirwa kwepasi rose uye kumwe kunatsiridzwa kwechikamu chepasi rose chevashandi vemakambani makuru emishonga emarudzi mazhinji, China yave nzvimbo yakakosha yepakati yekugadzira muchikamu chepasi rose chevashandi veindasitiri yemishonga. Maererano neKutsvagisa Chirevo pamusoro peKuvandudza kweChina's Pharmaceutical Intermediates Industry (2016), kubva muna 2011 kusvika muna 2015, indasitiri yemishonga yeChina yemishonga uye kukosha kwayo kwese kwakawedzera gore negore, nehuwandu hwekukura kwegore hunosvika 13.5%. yemishonga intermediates muChina yakasvika 422.56 bhiriyoni yuan muna 2015, kuwedzera 9,88% gore pagore. yuan na2020.Mufananidzo3.Indasitiri ine hunyanzvi hwepakati pemishongaIndasitiri iri kudiwa nekukurumidzira kugadzirisa uye kusimudzira: huwandu hwese hwehunyanzvi hweChina huchiri hushoma, uye kune mashoma emabhizinesi ari kugadzira huwandu hukuru hwepamberi hwemishonga yepakati uye inotsigira yepakati yemishonga mitsva ine patented, iri mukuvandudza. nhanho yekugadzirwa kwechigadzirwa optimization uye upgrading.Mamwe mabhizinesi chete ane tsvakiridzo yakasimba uye simba rekusimudzira, zvivakwa zvekugadzira zvepamberi uye ruzivo rwakakura rwekugadzira anogona kuwana purofiti yakakura mumakwikwi.Stable bhizinesi chiyero: Makuru-anogadzira vanotora yakagadziridzwa kugadzirwa seyavo huru. bhizinesi modhi.Pasi pemhando yekugadzira yakasarudzika, hukama hwekushandira pamwe pakati pevatengi vakuru nevatengesi hune kugadzikana, uye kuswedera pedyo kwekushandira pamwe, kunowedzera dhigirii rekuvimba, uye mapoka ekubatana anopihwa nevatengi vakuru achave. Zvinotora nguva yakareba kuchinja. suppliers.Naizvozvo, sebhizimusi rine kusimba kwakasimba, makambani emishonga epakati peindasitiri anonyanya kutarisisa makambani emishonga ekunze anonyanyozivikanwa panguva ino. nyika yakagadzikana.Kutengeswa kunze kwenyika zvakanyanya: nzvimbo huru dzekutengesa mishonga muChina iEU, North America, Middle East, Southeast Asia, etc.Kutengeswa kwenyika yedu kunonyanya kukoshesa vitamin C, penicillin, acetaminophen, citric acid. uye munyu wayo uye esters, senge zvigadzirwa, hunhu hwezvigadzirwa kugadzirwa kwezvigadzirwa, mabhizinesi ekugadzira, makwikwi emusika akanyanya, mutengo wechigadzirwa uye mutengo wakawedzerwa wakadzikira, kugadzirwa kwakawanda kwazvo kwakakonzera misika yepakati yemishonga yemusika. Zvigadzirwa zvepamusoro-soro zvichiri kunyanya kutengwa kunze kwenyika. Mabhizinesi madiki uye epakati nepakati: the production enterprZvizhinji zvemabhizimusi ega ega, mashandiro anochinjika, chiyero chekudyara hachisi chikuru, pakati pemamiriyoni kusvika gumi kana makumi maviri emamiriyoni yuan. Regional concentration: kugoverwa kwenharaunda kwemakambani ekugadzira kunenge kwakanyanya, kutenderedza mafekitori makuru emishonga, akaparadzirwa muTaizhou, Zhejiang. uye Jintan, Jiangsu sepakati pedunhu. Zhejiang Huangyan, Taizhou, Nanjing Jintan, Shijiazhuang, Jinan (kusanganisira Zibo), kuchamhembe kwakadziva kumabvazuva (Siping, Fushun) nedzimwe nzvimbo dzine mamiriro akanaka ekugadzirwa kwemishonga yepakati zvakakura zvakanyanya nekukurumidza. Kurumidza chigadzirwa chekuvandudza: chigadzirwa chinowanzo pamusika makore matatu kusvika mashanu gare gare, purofiti yacho inodonha zvakanyanya, izvo zvinomanikidza mabhizinesi kugara achigadzira zvigadzirwa zvitsva kana kugara achivandudza maitiro ekugadzira, kuitira kuchengetedza yakakwira purofiti. : nekuti purofiti yekugadzira yemishonga yepakati yakakwira kupfuura iyo of makemikari ezvigadzirwa, uye nzira yekugadzirwa kwezviviri zvakangofanana, makambani emakemikari maduku akawanda anobatana nekugadzirwa kwemishonga yepakati pemishonga, zvichiita kuti makwikwi anowedzera anotyisa asina kukodzera mumhizha.4.Mhando dzemishonga yepakatiKune marudzi akawanda emishonga epakati, anosanganisira cephalosporin intermediates, amino acid protectant series, vitamin intermediates, quinolone intermediates, nemamwe marudzi epakati, akadai semishonga inouraya utachiona hwepakati, antiepileptic drug intermediates, fluoropyridine intermediate, pharmacetics, etc. .Maererano neminda yavo yekushandisa, vanogona kukamurwa kuita antibiotic drug intermediates, antipyretic uye analgesic drug intermediates, cardiovascular system drug intermediates, anti-cancer drug intermediates nezvimwe zvakadaro.Parizvino, kune mazana emishonga yepakati pemishonga, uye nguva dzose. innovate, kuumba maindasitiri akawanda akanaka emolecular muindasitiri yemishonga.Kune marudzi mazhinji emhando dzakananga dzemishonga.Senge imidazole, furan, phenolic intermediates, aromatic intermediates, pyrrole, pyridine, biochemical reagents, sulfur, nitrogen, h.alogen compounds, heterocyclic compounds, microcrystalline cellulose, starch, mannitol, lactose, dextrin, ethylene glycol, shuga yehupfu, inorganic munyu, ethanol intermediates, stearic acid, amino acid uye ethanol amine munyu, sylvite, sodium munyu uye zvimwe zvepakati uye zvichingodaro. Mufananidzo 5.Patent CliffKubvira 2000, musika wepasi rose wemagetsi wakaramba uchikura nekukurumidza kupfuura musika wese wemishonga, uchikura nekaviri nekukurumidza semishonga ine patent. musika wezvinodhaka kubva 2005 kusvika 2013 unotarisirwa kusvika 14.7%.Musika wepasi rose wegenerics unotarisirwa kukura ne10% kusvika 14% mumakore mashanu anotevera, nekukurumidza zvakanyanya kupfuura zvaitarisirwa kukura kwe4% kusvika 6% kweindasitiri yese yemishonga. Zvinogona kufungidzirwa kuti kusimukira kwemusika wemishonga yegeneric kuchasimudzira kuvandudzwa kweindasitiri yemishonga yepakati.Kubva 2010 kusvika 2020, musika wepasi rose wemishonga uchaunza mafungu ekupera kwePatent, pakati pawo, kubva 2013 kusvika 2020, iyo yepasi rose yePatent kupera kwemarudzi ichaita avhareji kupfuura 200 gore rega rega, iyo inozivikanwa se "Patent Cliff" munyika.Muna 2014, pachava nepamusoro-soro yekupera kwemishonga patent, umo pachava nep.eak muna 2014, iine mazana matatu nemakumi maviri nenhanhatu emishonga patent ari kupera.2010 na2017 ndiwo makore maviri epamusoro-soro, aine mazana maviri neshanu uye 242 zvinodhaka patent zvichipera zvichiteerana.Mishonga yakapera inonyanya anti-infective, endocrine, nervous system uye mishonga yemwoyo, ine misika yakakura yemusika.Kupera kukuru kwemishonga ine mvumo yekunze kune dzimwe nyika kunounza zvitsva zvinokonzera kumishonga yemishonga yepakati muChina.Nekuti mushure mekupera kwepatent. madhiragi, kugadzirwa kwemishonga inechekuita negeneric kuchaputika, izvo zvichafambisa kukurumidza kukura kwechido chepakati chemishonga chine hukama.Mufananidzo6.Environmental pressureChina yatova mutengesi mukuru we API intermediates, pamwe nekusvibisa kukuru.Pharmaceutical yepakati vanogadzira ndevefine chemical industry, pachava nekuenderana nekusvibiswa kwengozi.According to statistics from the Ministry of Environmental Protection, the total output value of the indasitiri yemishonga yemumba inodarika 3 muzana yeGDP yenyika, asi huwandu hwehuwandu hwekusvibiswa kwemhepo hunosvika 6 muzana. Pakati pemarudzi ese emishonga, API inonyanya kumiririrwa nemavhitamini uye penicillin ndeyeindasitiri yekusvibiswa kwakanyanya uye kushandiswa kwesimba kwakanyanya, Zvinoenderana nekutumirwa kwakabatana kweMinistry of Environmental Protection, musi waFebruary 15, 2017, boka rekuongorora rakakosha yehutano hwemhepo mukota yekutanga ye2017 yakazivisa kuti kushandiswa kwemhepo muShijiazhuang kwakanga kusiri. panzvimbo, uye hurumende yedunhu yakanga ichiri kunyanya kuenderana neEnvironmentl Vashandi veProtection Bureau mukushandiswa kwehurongwa hwekusvibisa mamiriro ekunze, nepo mamwe madhipatimendi asina kubatanidzwa mune yakakwira dhigirii.Kusvibiswa kwemabhizinesi madiki nepakati anogadzira epakati pemishonga muShijiazhuang kwakakomba.Mabhizinesi emishonga ane tekinoroji yekudzokera shure achabereka mari yekudzora kusvibiswa kwepamusoro uye kumanikidzwa kwemitemo, uye makambani emishonga echinyakare anonyanya kugadzira kusvibiswa kwakanyanya, kushandiswa kwesimba rakawanda uye zvigadzirwa zvakaderera (senge penicillin, mavhitaminzi, nezvimwewo) zvichatarisana nekukurumidzira kubviswa. rave remangwana budiriro nhungamiro yemishonga intermediates industry.Mufananidzo
7. Vatungamiri vemaindasitiri
mit-ivy industry
Zhejiang NHU Company Ltd.Plo Co., Ltd
Lianhe Chemical Technology Co., Ltd.Anhui Bayi Chemical Co. Ltd.Zhejiang Huahai Pharmaceutical Co. Specialty Chemicals Co., Ltd.